THE EFFECT OF BILATERAL ADRENALECTOMY ON ARTERIAL BLOOD PRESSURE OF DOGS WITH EXPERIMENTAL HYPERTENSION

Abstract

The adrenal cortex is important in the mechanism responsible for the development of renal hypertension in dogs. The adrenal medulla, ovaries and testes are not essential for the maintenance of renal hypertension in dogs. Maintenance doses of adrenal cortical extract and possibly salt are necessary for persistence of moderate hypertension in dogs with both renal arteries constricted and the hypophysis, testes, and adrenal glands removed. Endocrine glands are concerned chiefly with maintenance of the body in a responsive state so that hypertension can develop during constriction of the renal arteries.