Studies of47Ca Metabolism in Acromegaly
- 1 February 1967
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 27 (2), 178-184
- https://doi.org/10.1210/jcem-27-2-178
Abstract
Calcium and phosphorus metabolism was studied in 4 patients with acromegaly, 2 of whom had received pituitary irradiation. Calcium and phosphorus balance, exchangeable calcium (P[image]) calcium "accretion" rate (vo +) and "bone resorption" rate (vo[long dash]) were measured. In all patients there was a negative calcium balance; in 3 of them there was a negative phosphorus balance. Urinary calcium was moderately increased in the 2 untreated patients, and normal in the 2 treated patients. Inallpatients, vo + and vo - were abnormally increased. These results are comparable to those which have been produced in normal subjects with human growth hormone. These findings support the view that vo + and vo[long dash]are abnormally increased in acromegaly and that the increase results from growth hormone. The possible relationship of the results to osteoporosis is discussed.Keywords
This publication has 16 references indexed in Scilit:
- CHANGES IN THE METABOLISM OF CALCIUM AND PHOSPHORUS IN THE VARIOUS PHASES OF ACROMEGALY AND FOLLOWING THE IMPLANTATION OF THE PITUITARY GLAND WITH 90YActa Endocrinologica, 1961
- EFFECTS OF HUMAN GROWTH HORMONE IN MAN *JCI Insight, 1960
- STRONTIUM AND CALCIUM METABOLISM IN METABOLIC BONE DISEASES *JCI Insight, 1960
- Méthode de mesure des principales voies du métabolisme calcique chez l'hommeBiochimica et Biophysica Acta, 1960
- THE EFFECT OF HUMAN GROWTH HORMONE IN MANActa Endocrinologica, 1959
- THE RELATION BETWEEN EXTRACELLULAR AND INTRACELLULAR WATER IN ACROMEGALYActa Endocrinologica, 1956
- THE CLINICAL DETERMINATION OF PROTEIN-BOUND IODINE 1JCI Insight, 1951
- Experience with a Quantitative Test for Normal or Decreased Amounts of Follicle Stimulating Hormone in the Urine in Endocrinological DiagnosisJournal of Clinical Endocrinology & Metabolism, 1943
- STUDIES OF CALCIUM AND PHOSPHORUS METABOLISM. XVI. THE INFLUENCE OF THE PITUITARY GLAND 1JCI Insight, 1941
- Über Wirbelsäulenveränderungen bei AkromegalieVirchows Archiv, 1931