The discrimination of phenotypes for rate of disappearance of isonicotinoyl hydrazide from serum
Open Access
- 1 July 1969
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 48 (7), 1173-1176
- https://doi.org/10.1172/jci106081
Abstract
Expression of the rate of inactivation of isonicotinoyl hydrazide (INH) as a first-order constant gave better discrimination of slow and rapid inactivators than did the level of INH at the end of 6 hr. The most probable division point between the two classes was at k = 0.130. Rate of inactivation by obligatory heterozygotes was determined. Such heterozygotes could not be adequately differentiated from homozygous rapid inactivators. The gene frequency for slow inactivation was 0.46 ±0.04 in Alaskan Eskimos and 0.62±0.06 in Athabaskan Indians.Keywords
This publication has 6 references indexed in Scilit:
- FLUOROMETRIC DETERMINATION OF ISONICOTNIC ACID HYDRAZIDE IN SERUM1967
- Genetics of Isoniazid Metabolism in Caucasian, Negro, and Japanese PopulationsScience, 1964
- Genetical and Geographic Studies on Isoniazid InactivationScience, 1961
- Genetic Control of Isoniazid Metabolism in ManBMJ, 1960
- A comparison between the behavior of Eskimos and non-Eskimos to the administration of isoniazid.Published by Elsevier ,1960
- Studies of Human Patterns of Isoniazid Metabolism Using an Intravenous Fall-off Technique with a Chemical Method1American Review of Respiratory Disease, 1960