The discrimination of phenotypes for rate of disappearance of isonicotinoyl hydrazide from serum
Open Access
- 1 July 1969
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 48 (7), 1173-1176
- https://doi.org/10.1172/jci106081
Abstract
Expression of the rate of inactivation of isonicotinoyl hydrazide (INH) as a first-order constant gave better discrimination of slow and rapid inactivators than did the level of INH at the end of 6 hr. The most probable division point between the two classes was at k = 0.130. Rate of inactivation by obligatory heterozygotes was determined. Such heterozygotes could not be adequately differentiated from homozygous rapid inactivators. The gene frequency for slow inactivation was 0.46 ±0.04 in Alaskan Eskimos and 0.62±0.06 in Athabaskan Indians.This publication has 6 references indexed in Scilit:
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