Application of nanogel systems in the administration of local anesthetics

Abstract

Application of nanogel systems in the administration of local anesthetics Jeremy PK Tan1, Maureen BH Tan2, Michael KC Tam31Institute of Bioengineering and Nanotechnology, Agency for Science Technology and Research, Singapore; 2Institute of Materials Research and Engineering, Agency for Science Technology and Research, Singapore; 3Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, Canada Nanogels are robust nanoparticles that could be used to deliver active drug ­compounds in controlled drug delivery applications. This review discusses the design, synthesis, loading, and release of local anesthetics using polymeric nanoparticles produced via various types of polymerization techniques. The strategy of using layer-by-layer approach to control the burst release of procaine hydrochloride (PrHy; a local anesthetic drug of the amino ester group) is described and discussed.Keywords: nanogels, nanoparticles, active drug compounds, local anesthetics, polymeric nanoparticles, procaine hydrochloride (PrHy)