Triglyceride Storage Disease: A Disorder of Lipolysis in Adipose Tissue in Two Patients
- 6 January 1973
- Vol. 1 (5844), 25-27
- https://doi.org/10.1136/bmj.1.5844.25
Abstract
An obese patient was studied whose adipose tissue showed a significant reduction in release of glycerol (P < 0·05) when stimulated by isoprenaline despite normal rises in tissue levels of cyclic-AMP. However, lipolysis was stimulated by a fast of 14 days as judged by weight loss and a rise in plasma fatty acids from 0·4 to 1·2 mM. The defect in this patient may be familial since her obese daughter also showed diminished release of glycerol from adipose tissue on three occasions when stimulated by isoprenaline, despite normal rises in levels of cyclic-AMP.Keywords
This publication has 6 references indexed in Scilit:
- A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphateBiochemical Journal, 1971
- Loss of cyclic 3′5′-AMP dependent kinase and reduction of phosphorylase kinase in skeletal muscle of a girl with deactivated phosphorylase and glycogenosis of liver and muscleBiochemical and Biophysical Research Communications, 1970
- Studies on the role of RNA and protein synthesis in the lipolytic action of growth hormone in isolated fat cellsAdvances in Enzyme Regulation, 1967
- Studies on Adipose Tissue from Obese Patients with or without Diabetes MellitusActa Medica Scandinavica, 1966
- A Rapid Enzymatic Assay for GlycerolNature, 1962
- Response of Plasma NEFA Levels to Epinephrine Infusions in Normal and Obese Women.Experimental Biology and Medicine, 1960