A Randomized Trial of the Efficacy and Tolerability of the COX-2 Inhibitor Rofecoxib vs Ibuprofen in Patients With Osteoarthritis
Open Access
- 26 June 2000
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 160 (12), 1781-1787
- https://doi.org/10.1001/archinte.160.12.1781
Abstract
NONSTEROIDAL anti-inflammatory drugs (NSAIDs) are commonly used to treat the pain and inflammation caused by a variety of clinical disorders, including osteoarthritis (OA). The clinical effects of these drugs result primarily from the inhibition of the enzyme cyclooxygenase (COX), the first step in the conversion of arachidonic acid to prostaglandins.1Keywords
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