The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37
- 1 May 1987
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 51 (2), 145-152
- https://doi.org/10.1111/j.1469-1809.1987.tb01056.x
Abstract
A human placental alkaline phosphatase (PLAP) eDNA was isolated from a Λgt10 library of the cell line HEp-2. Southern blots probed with a fragment of the eDNA clone showed that the human genome may contain more than one PLAP-related sequence. The PLAP probe showed person-to-person variation in banding pattern with a number of enzymes. Using a panel of human/rodent somatic cell hybrids the PLAP sequences were mapped to chromosome 2. In situ hybridization confirmed this assignment and localized the gene(s) to chromosome 2 band q37.Keywords
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