Self-Replication of Enterochromaffin-Like Cells in the Mouse Stomach
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 45 (3), 138-146
- https://doi.org/10.1159/000200235
Abstract
The renewal mechanisms for enterochromaffin-like (ECL) cells, the predominating endocrine cell population in the oxyntic mucosa of the stomach, were investigated in the mouse. The ECL cells were selectively demonstrated by immunostaining using histamine antibodies. Under basal conditions, when observed during the night, ECL cells in mitosis could be seen. This observation proved their ability to divide. Autoradiography after a single pulse and after multiple injections of 3H-thymidine made it possible to study some of their cytokinetic characteristics. The observed replication rate of the labeled ECL cells suggested that self-replication is the main mechanism by which the ECL cell population is renewed. The time interval between two successive divisions of labeled ECL cells was estimated to be around 60 days. Since ECL cells proliferate through mitosis, it may be expected that specific mitogenic stimuli might promote the induction of ECL cell hyperplasia and eventually ECL cell tumors (gastric carcinoids).Keywords
This publication has 17 references indexed in Scilit:
- Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemiaGastroenterology, 1985
- ELECTRON-MICROSCOPIC IDENTIFICATION OF HISTIDINE DECARBOXYLASE-CONTAINING ENDOCRINE-CELLS OF THE RAT GASTRIC-MUCOSA - AN IMMUNOHISTOCHEMICAL ANALYSIS1984
- Self-replication of somatostatin cells in the antral mucosa of rodentsCell Proliferation, 1982
- Tritiated thymidine autoradiographic study on origin and renewal of gastrin cells in antral area of hamstersGastroenterology, 1980
- Effect of antrum exclusion on endocrine cells of rat stomach.The Journal of Physiology, 1979
- Tritiated thymidine autoradiographic study on the origin and renewal of argentaffin cells in the pyloric gland of hamstersCell and tissue research, 1977
- Population Kinetics of Antral Gastrin Cells in the MouseGastroenterology, 1976
- Effects of antrectomy or porta‐caval shunting on the histamine‐storing endocrine‐like cells in oxyntic mucosa of rat stomach. A fluorescence histochemical, electron microscopic and chemical study.The Journal of Physiology, 1976
- Cell Proliferation and Migration in the Stomach, Duodenum, and Rectum of Man: Radioautographic StudiesGastroenterology, 1964
- Renewal of the mucous cells in the gastric mucosa of the ratThe Anatomical Record, 1953