Emodin Isolated from Cassia obtusifolia (Leguminosae) Seed Shows Larvicidal Activity against Three Mosquito Species
- 14 November 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 51 (26), 7629-7631
- https://doi.org/10.1021/jf034727t
Abstract
Mosquito larvicidal activity of Cassiaobtusifolia (Leguminosae) seed-derived materials against the fourth-instar larvae of Aedes aegypti, Aedes togoi, and Culex pipiens pallens was examined. The chloroform fraction of C.obtusifolia extract showed a strong larvicidal activity of 100% mortality at 25 mg/L. The biologically active component of C.obtusifolia seeds was characterized as emodin by spectroscopic analyses. The LC50 values of emodin were 1.4, 1.9, and 2.2 mg/L against C. pipiens pallens, A. aegypti, and A. togoi, respectively. Pirimiphos-methyl acts as a positive control directly compared to emodin. Pirimiphos-methyl was a much more potent mosquito larvicide than emodin. Nonetheless, emodin may be useful as a lead compound and new agent for a naturally occurring mosquito larvicidal agent. In tests with hydroxyanthraquinones, no activity was observed with alizarin, danthron, and quinizarin, but purpurin has an apparent LC50 value of ∼19.6 mg/L against A. aegypti. Keywords: Aedes aegypti; Cassiaobtusifolia; Culex pipiens pallens; emodin; mosquito larvicidal activityKeywords
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