Localization and Pyrazinamide Inhibition of Distal Transtubular Movement of Uric Acid-2-C14 with a Modified Stop-Flow Technique*

Abstract

By a modification of the stop-flow technique and the renal arterial injection of uric acid-2-C14 just before the reestablishment of urine flow, transtubular movement of uric acid in the mongrel dog was localized to a distal portion of the nephron. Pyrazinamide, a drug known to increase serum uric acid levels by decreasing renal excretion of urate, was demonatrated to inhibit this distal tubular movement of uric acid.