Tin: A Potent Inducer of Heme Oxygenase in Kidney
- 2 April 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 192 (4234), 60-62
- https://doi.org/10.1126/science.1257757
Abstract
Tin greatly enhances heme breakdown in kidney, thus impairing heme-dependent cellular functions, such as cytochrome P-450 mediated drug biotransformation. This novel action of the metal results from a potent induction effect on heme oxygenase, the enzyme that catalyzes heme oxidation in microsomes. The possible toxicological implications of this tin effect in the kidney merit further investigation.This publication has 12 references indexed in Scilit:
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