Congenital leukoderma is described in all textbooks under the name of partial albinism. The condition consists of achromic patches, irregularly distributed and often symmetrically situated. These patches are milky white, closely resembling those of vitiligo. Congenital leukoderma differs from vitiligo in being present at birth, in being hereditary with approximately the same distribution in all subjects of the same family, in the absence of peripheral pigmentation and in being fixed, neither growing nor diminishing in size in later years. The cases reported were seen through the courtesy of Dr. J. A. Tremols of Havana. The patients were a mother and three children, 32, 4, 3 years and 8 months of age, respectively, all white, from direct Spanish ancestors, the possibility of any admixture of colored blood being carefully excluded. All of them presented extensive achromic patches over the chest, abdomen, legs and arms, of similar size and shape. In the