Physiological uptake of [18F]fluorodeoxyglucose in the neck and upper chest region: are there predictive characteristics?

Abstract

Objective The purpose of this study was to assess (patient) characteristics that might influence the prevalence of physiological uptake of [¹⁸F]fluorodeoxyglucose (FDG) in the neck and upper chest region (FDG NUC) in positron emission tomography (PET) imaging. Methods Retrospective study of static FDG PET scans in patients with malignant lymphoma, head and neck, lung or thyroid malignancy. The investigated determinants were gender, age, body mass index (BMI), tumour type, referring centre (community or university hospital), first or later PET scan, and use of benzodiazepines. Results Eighty (31%) of 260 scans showed FDG NUC. We found a strong inverse relation between age and FDG NUC (PP=0.011). Gender, use of benzodiazepines, referring specialist, first or later PET scan or low BMI (−2) did not influence the prevalence of FDG NUC. Conclusion Multivariate logistic regression showed a strong inverse association between age and FDG NUC. No association between low BMI and FNUC could be established. In our hospital no protective effect of benzodiazepines could be determined. These data suggest that a trial designed to evaluate the efficiency of interventions to diminish FDG NUC should focus on younger patients.