Zur Biosynthese der Peptidalkaloide von Claviceps purpurea / Biosynthesis of Peptide Alkaloids of Claviceps purpurea

Abstract

Using a strain of Claviceps purpurea which produces under submerged conditions chanoclavine, ergometrine and mainly ergotoxine the biosynthesis of ergoline derivatives has been studied. DL-Tryptophan- (ring-2-¹⁴C) is specifically incorporated into the lysergic acid moiety of ergotoxine· alkaloids. L-Proline-U-¹⁴C serves as a precursor of the proline-part of the peptid-chain of ergotoxine.