Enhancing Effect of Levamisole on the Phagocytic Activity of Human Neutrophil Polymorphonuclear Leucocytes in vitro
- 1 July 1977
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 19 (1), 93-98
- https://doi.org/10.1111/j.1600-0609.1977.tb02724.x
Abstract
The effect of levamisole on the phagocytic activity of normal human polymorphonuclear neutrophil leucocytes has been studied in vitro. In concentrations comparable with the serum levels obtained in treatment with levamisole perorally, the engulfment of heat-killed yeast cells is moderately but significantly increased. It is shown that levamisole can only stimulate phagocytosis of adequately opsonized particles. The action of the drug is still unknown but appears to be directly linked to the phagocytic cell.Keywords
This publication has 11 references indexed in Scilit:
- In Vitro Stimulation of Neutrophil Motility by Levamisole: Maintenance of cGMP Levels in Chemotactically Stimulated Levamisole-Treated NeutrophilsThe Journal of Immunology, 1976
- Effect of Levamisole on E-Rosette-Forming Cells in Vivo and in Vitro in Hodgkin's DiseaseNew England Journal of Medicine, 1976
- IMPAIRED NEUTROPHIL PHAGOCYTOSISThe Lancet, 1974
- Immunological phagocytosis: Effect of drugs on phosphodiesterase activityCellular and Molecular Life Sciences, 1974
- ENHANCED HOST DEFENSE MECHANISM WITH PHENYL-IMIDOTHIOZOLEPediatric Research, 1974
- Drug-Induced Restoration of Cutaneous Delayed Hypersensitivity in Anergic Patients with CancerNew England Journal of Medicine, 1973
- Enhancing Effect of Clofazimine (B663) on the Phagocytosis of Neutrophilic Leucocytes in VitroScandinavian Journal of Haematology, 1971
- Phagocytic activity of neutrophil leucocytes in pustulosis palmo-plantaris, chronic discoid lupus erythematosus and erysipelasActa Dermato-Venereologica, 1971
- Levamisole in the treatment of ascariasis in childrenBMJ, 1969
- Tetramisole (R 8299), A New, Potent Broad Spectrum AnthelminticNature, 1966