Studies of Red-Cell Volume and Turnover Using Radiochromium

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Abstract
THE successful management of many clinical problems depends on information regarding the total volume of the mass of red cells in the body. The concentration of these cells in the peripheral blood is widely used as an index of total volume. The value of this determination depends on the accuracy with which it measures the over-all distribution of cells and plasma in the circulation. Changes in the hematocrit percentage of the peripheral blood can only reflect alterations in the size of the red-cell mass if the plasma volume remains constant. Keith et al.1 showed in 1921 that the ratio of . . .