Reticuloendothelial system blockade-induced humoral factor depletion and susceptibility to hemorrhagic shock
- 1 December 1978
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 56 (6), 1055-1057
- https://doi.org/10.1139/y78-169
Abstract
This study was carried out to determine if reticuloendothelial system (RES) Mockade-induced depletion of circulating alpha-2-glycoprotein opsonic activity resulted in increased susceptibility to hemorrhagic shock. RES blockade induced by the injection of gelatinized lipid emulsion was associated with a 45.9% decrease in phagocytic index and a 85.7% decrease in plasma alpha-2-glycoprotein opsonic activity. Animals subjected to RES blockade 30 min prior to hemorrhagic shock showed a decrease in time to decompensation and a decrease in maximum shed volume. These results are consistent with the concept that circulating levels of this opsonic protein are important in modulating RES phagocytic function and in host defense to shock.This publication has 7 references indexed in Scilit:
- Humoral factor depletion and reticuloendothelial depression during hemorrhagic shockAmerican Journal of Physiology-Heart and Circulatory Physiology, 1977
- Bioassay of endotoxin clearance in vivo and by perfused rat liverAmerican Journal of Physiology-Legacy Content, 1976
- Destruction of injured red cells in vivoAmerican Journal Of Medicine, 1966
- Effect of Phenoxybenzamine on Phagocytic Activity and Shock Mortality in the Rat.Experimental Biology and Medicine, 1964
- IMMUNOHISTOCHEMICAL DEMONSTRATION OF THE RETICULOENDOTHELIAL CLEARANCE OF CIRCULATING FIBRIN AGGREGATESThe Journal of Experimental Medicine, 1962
- THE ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN HEMORRHAGIC SHOCKThe Journal of Experimental Medicine, 1959
- THE RELATIONSHIP BETWEEN THE VASCULAR MANIFESTATIONS OF SHOCK PRODUCED BY ENDOTOXIN, TRAUMA, AND HEMORRHAGEThe Journal of Experimental Medicine, 1957