Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival
Open Access
- 26 November 2008
- journal article
- Published by Springer Nature in BMC Gastroenterology
- Vol. 8 (1), 56
- https://doi.org/10.1186/1471-230x-8-56
Abstract
The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between PTEN expression and clinicopathological characteristics of colorectal cancer patients with and without liver metastases, we investigated PTEN expression in primary colorectal cancer and colorectal cancer liver metastases.Keywords
This publication has 33 references indexed in Scilit:
- PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor CetuximabCancer Research, 2008
- PTEN: One Gene, Many SyndromesHuman Mutation, 2003
- Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch RecombinationThe Journal of Experimental Medicine, 2003
- Wortmannin inhibits growth of human non-small-cell lung cancer in vitro and in vivoLangenbecks Archives Of Surgery, 2002
- Reversible Inactivation of the Tumor Suppressor PTEN by H2O2Journal of Biological Chemistry, 2002
- Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in VivoScience, 2001
- Cellular survival: a play in three AktsGenes & Development, 1999
- Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTENScience, 1998
- Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transductionNature, 1995
- AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.Proceedings of the National Academy of Sciences, 1992