Rap1 GTPase Regulation of Adherens Junction Positioning and Cell Adhesion
- 15 February 2002
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 295 (5558), 1285-1288
- https://doi.org/10.1126/science.1067549
Abstract
Cell-cell junctions are distributed evenly around the lateral circumference of cells within an epithelium. We find that the even distribution of adherens junctions is an active process that requires the small guanosine triphosphatase Rap1. Cells mutant forRap1 condensed their adherens junctions to one side of the cell. This disrupted normal epithelial cell behavior, and mutant cell clones dispersed into the surrounding wild-type tissue. Rap1 is enriched at adherens junctions, particularly between newly divided sister cells where it may reseal the adherens junction ring. The regulation of adherens junction positioning could play a role in cell mobility and cell division.Keywords
This publication has 23 references indexed in Scilit:
- Dynamic features of adherens junctions during Drosophila embryonic epithelial morphogenesis revealed by a D α-catenin-GFP fusion proteinWilhelm Roux' Archiv für Entwicklungsmechanik der Organismen, 1999
- The Rap1 GTPase functions as a regulator of morphogenesis invivoThe EMBO Journal, 1999
- The role of RhoA in tissue polarity and Frizzled signallingNature, 1997
- The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1.Genes & Development, 1996
- A Drosophila Homolog of Cadherin Associated with Armadillo and Essential for Embryonic Cell-Cell AdhesionDevelopmental Biology, 1994
- Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression.Proceedings of the National Academy of Sciences, 1994
- Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteinsBiochemical Journal, 1993
- The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctionsCell, 1991
- Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.The Journal of cell biology, 1986
- Lakes Beneath the Antarctic Ice SheetNature, 1973