A SIMPLE METHOD FOR DEMONSTRATING GEL-PRECIPITATING HUMAN ANTIIMMUNOGLOBULIN ANTIBODIES
- 1 December 1977
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Section C Immunology
- Vol. 85C (6), 480-482
- https://doi.org/10.1111/j.1699-0463.1977.tb03672.x
Abstract
The use of aggregated human IgG for the detection of anti-immunoglobulin antibodies by double immunodiffusion in gel is described. Of rheumatoid arthritis sera, 54 of 56 sera having a Waaler-Rose test titre of ≥ 1:16 contained antibodies to aggregated IgG, in contrast to only 2 of 52 sera from blood donors. Furthermore, after 2-mercapto-ethanol treatment anti-IgG was still demonstrated in 5 of 16 sera.Keywords
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