Goldthioglucose-Induced Hypothalamic Lesion and AGTH Release.
- 1 November 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 108 (2), 377-380
- https://doi.org/10.3181/00379727-108-26944
Abstract
Goldthioglucose (GTG) was injected intraperitoneally (0,4 mg/g body weight) in mice (males and females) of CBA strain (90 to 120 days old). GTG produces consistently a lesion in the ventral hypothalamus which is followed by development of obesity. This lesion does not interfere with the mechanisms responsible for secretion of ACTH upon exposure to stress (ether or ether + fracture of a leg). Criterion for evidence of ACTH -secretion was measurement of plasma free-corticosterone by SO7H2 induced fluorescence.Keywords
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