Menotropins (human menopausal gonadotropin) was used in the treatment of infertility in a group of 236 patients. Ovulation was frequently accomplished when this hormonal preparation was used in instances where prior use of clomiphene citrate alone had failed. Forty-two pregnancies occurred during treatment, an incidence of 17%, which is lower than the unpublished totals for all investigators, in which the incidence is 24%. The lower figure may be related to the nature of the patients in this series, many of whom had very poor prognoses, and the occurrence of a number of these pregnancies might be considered quite remarkable. For this reason, the use of menotropins in certain patients with infertility may be justified despite the high incidence of multiple births and the great care with which menotropins must be used to avoid severe untoward reactions.