Influence de la température sur le développement du virus Sindbis et la production d'interféron en cultures cellulaires

Abstract

The development of Sindbis virus in mouse embryo fibroblasts was found to vary according to the temperature of incubation. An augmentation in these temperatures was followed by a prolongation of the lag period and a decrease in the final yield. At 38 °C, 39 °C, and 40 °C the virus titer was respectively 50%, 16%, and 1.3% of that observed at 36 °C.Interferon production at 38 °C was equal to, or greater than, at 36 °C but at 39 °C and 40 °C it was respectively 1.4 and 5 times lower than that found at 36 °C.These results permit us to presume that the inhibition of Sindbis virus development at supra-optimal temperatures cannot be attributed to an increase of interferon production.