Recurrent Cushing's Syndrome with Trichophyton Rubrum Infection

Abstract

The effects of adrenal hypercorticism on bacterial infections are well recognized. The effects of hypercorticism on mycotic infections are not as widely appreciated. The following case warrants reporting because the patient shows dramatically the effect of hyperadrenocorticism on a Trichophyton rubrum infection. The steroid assays on this patient with adrenal hyperplasia and adenomas were within the levels usually found in adrenal malignancy. Report of a Case A white married engineer, aged 30, was seen at the Clinic in June, 1954, because of progressive weakness of six months' duration, obesity, known hypertension, and a dermatitis which had first appeared in September of 1953. Pertinent physical findings at that time were moderate obesity (height 72 in., weight 220 lb.), a blood pressure of 200/140 (which dropped rapidly to 140/100 on bed rest and reserpine), and electrocardiographic evidence of early left ventricular hypertrophy. Erythematous, scaling plaques, more active at