Postoperative pain control with intrathecal morphine
Open Access
- 1 March 1981
- journal article
- Published by Wiley in Anaesthesia
- Vol. 36 (3), 268-276
- https://doi.org/10.1111/j.1365-2044.1981.tb10199.x
Abstract
A clinical study of the use of intrathecal morphine in two groups of surgical patients, 32 in all, showed that the morphine provided very powerful and prolonged analgesia with little disturbance of cerebral function. When combined with a spinal block it did not interfere with the action of the spinal anaesthetic. When combined with a relaxant technique of anaesthesia some persistent curarisation was seen. The only complication to emerge from the study was respiratory depression which could be very delayed in its onset. The depression was sufficient to induce carbon dioxide narcosis in two patients. It is suggested that the dose of intrathecal morphine in the very elderly should be very severely restricted as they appeared to be unduly sensitive to the respiratory depressant effect of morphine when given intrathecally.Keywords
This publication has 14 references indexed in Scilit:
- INTRATHECAL MORPHINE IN OPEN HEART SURGERYThe Lancet, 1980
- SELECTIVE SPINAL ANALGESIAThe Lancet, 1979
- SPINAL NARCOTICS AND RESPIRATORY DEPRESSIONThe Lancet, 1979
- Patterns of postoperative pain.Anaesthesia, 1979
- EPIDURAL MORPHINEThe Lancet, 1979
- Pain Relief by Intrathecally Applied Morphine in ManAnesthesiology, 1979
- Analgesia Mediated by a Direct Spinal Action of NarcoticsScience, 1976
- Identification of two related pentapeptides from the brain with potent opiate agonist activityNature, 1975
- THE KINETIC THEORY OF SHOCK AND ITS PREVENTION THROUGH ANOCI-ASSOCIATION (SHOCKLESS OPERATION).The Lancet, 1913