Four reports of anaphylactic reactions from penicillin have been found in the literature, in all of which the reactions were secondary to intramuscular injections.1 The following cases are of interest because up to the time of writing there had been no report of similar reactions due to the local use or topical application of penicillin. REPORT OF CASES Case 1.— A white man, aged 57 years, in good general health except for moderate hypertension and recurring upper respiratory tract infections, was treated on Nov. 26, 1949 for subacute left maxillary sinusitis. The left antrum was irrigated through the natural ostium, and 1 cc. of mucopus was returned. The saline solution was displaced by air, and 30,000 units of crystalline penicillin G and 9.9 mg. of 1-ephedrine in 4 cc. of 2.5 per cent "sulfisoxazole" (gantrisin®—3,4-dimethyl-5-sulfanilamido isoxazole) were instilled into the antrum. The patient had an almost immediate flushing of