Creatine phosphokinase and other serum enzyme activity after controlled exercise

Abstract

Although there is conflicting evidence in past reports, most data suggest strenuous exercise in man and lower animals will cause transient elevation of SCOT (glutamic oxaloacetic transaminase). Studies which subjected human subjects to strenuous controlled exercise over a 10 minute period did not reveal any significant increase in serum concentration of CPK (creatine phos-phokinase), SGOT, SGPT (glutamic pyruvic transaminase), LDH (lactic dehydrogenase), MDH malic dehydrogenase or ALD aldolase. It is concluded that the exercise was not of sufficient duration or severity to produce changes previously reported in the literature. Studies utilizing assay of enzymes, specific for muscle, should allow separation of the possible contribution of hepatic enzyme leak to the overall increase in the serum enzyme activity reported by other authors.