Elevation of Serum Angiotensin-Converting Enzyme in Gaucher's Disease

Abstract

MEASUREMENT of serum angiotensin-converting enzyme has been found useful for confirming a diagnosis of active sarcoidosis.¹ The mean serum level in patients with active sarcoidosis is twice that found in healthy controls or in patients with other types of chronic lung or granulomatous disease. Elevations of this serum enzyme activity are believed to result from the release or loss of the enzyme from epithelioid cells of the sarcoid granulomata.² The serum level returns to normal in sarcoidosis with either spontaneous resolution of the disease or with therapeutic doses of corticosteroid medication. Thus, the elevated enzyme levels are not due to . . .