Induction of Antinuclear Antibodies in Mice Inoculated with Pauscher Leukemogenic Virus: Possible Role of Genetic Factors in “Non-New Zealand” Strains

Abstract

Mice belonqing to strains with a low incidence of spontaneous antinuclear antibodies (C 57 B1/6, BALB/c, C3H/eb and their F1 hybrids) were inoculated with a given dose of Rauscher leukemgenic virus (RLV). Two months after inoculation, a significant increase in ANF incidence was observed in c/B6 and C3H/B6 F1 hybrids, but not in C3H/c hybrids or in the three parental strains. These results, compared to those observed in other experimental models, suggest that several genes are implicated in ANG induction by RLV, and chat one of them could play a role in the handling of chronic infection with this leukemgenic virus.