Differentiation inducers of human promyelocytic leukemia cells HL-60. Azobenzenecarboxylic acids and stilbenecarboxylic acids.

Abstract
Azobenzene-4-carboxylic acid derivatives are a new type of differentiation inducers of human myelogenous leukemia cell line HL-60. Induced cells are morphologically and functionally mature granulocytes. A study of substituent effects indicated that these compounds are related to the known synthetic retinoid, tetrahydrotetramethylnaphthylpropenylbenzic acid.