Malignant lymphoma originating in the stomach is an uncommon but important lesion; it accounts for about 2 per cent of all gastric malignant neoplasms. Patients with lymphoma localized to the stomach and perigastric nodes are well known to have a more favorable prognosis than those with carcinoma of this organ. Much has been written about the radiologic findings in cases of malignant lymphoma of the stomach (7, 8). While many authors conclude that a specific roentgen-ographic diagnosis of this lesion is usually not possible (1, 6, 9, 10, 12, 13), they stress that radiographic examination of the stomach will reveal its presence, site, and extent, and usually will also indicate its neoplastic nature. The present study is based on 72 cases of primary gastric lymphoma collected from the files of the Mayo Clinic from 1951 through 1960. In all, the diagnosis was established by surgical exploration and the histologic study of either surgical specimens or biopsy material. In every instance the medical records and microscopic slides were reviewed, and the available surgical specimens and roentgenograms were studied. The investigation was conducted in the hope of finding radiographic signs, on the basis of which a tentative diagnosis of gastric lymphoma could be made or at least suggested. Clinical Aspects The ages of our 72 patients ranged from thirty-two to eighty-two years with an average of fifty-seven and nine-tenths years. As in other studies (10, 12) a slight predilection for males was found, with a ratio of 1.6∶1. The duration of symptoms before diagnosis varied from one to thirty months with a mean of six months. The pertinent symptoms are presented in Table I. The most frequent complaint, epigastric pain, often simulated the pain of peptic ulcer, and several patients reported temporary benefit from medical ulcer treatment. Loss of weight was another common symptom. The amount of such loss correlated directly with the duration of symptoms; patients with symptoms of less than six months averaged 14 pounds of weight loss while those with a longer duration of symptoms showed a mean weight loss of 25.5 pounds. Hematemesis and melena were noted in approximately 20 per cent of the cases. One such patient was admitted to the hospital in a state of shock resulting from severe gastrointestinal hemorrhage. One patient reported progressive dysphagia as the chief complaint, and 2 presented symptoms of pyloric obstruction. Two others were admitted as emergencies with the findings of an acute surgical abdomen; abdominal exploration revealed perforation of a gastric lymphoma in both instances. A single patient was completely asymptomatic, an epigastric mass being found on physical examination. Laboratory findings were rarely impressively positive. The concentration of hemoglobin was less than 12 g in 31 patients (43 per cent) and less than 10 g in 10 (14 per cent).