Intervening sequence between the leader region and the nucleopcapsid gene of vesicular stomatitis virus RNA
- 1 February 1980
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 33 (2), 789-794
- https://doi.org/10.1128/jvi.33.2.789-794.1980
Abstract
The base sequence at the 3'' end of vesicular stomatitis virus RNA was determined by using terminal labels and chemical RNA sequencing. The leader RNA was complementary to 47 bases at the 3'' terminus, whereas the nucleocapsid gene (N) began 51 nucleotides from the 3'' end of the genomic RNA. The intervening bases were 3'' ... GAAA ... 5'' for the Indiana serotype and 3'' ... GAAA ... 5'' for the New Jersey serotype. The complements of these bases did not appear in either the leader RNA or the N mRNA. This sequence may function as a stop signal or cleavage site during transcription. Processing of termination at this sequence must be inhibited during the production of full-length RNA plus-sense strands (replication). Similar sequences, approximately 46-48 nucleotides were found recently from the 3'' ends of several defective interfering particle RNA where the short defective interfering particle transcription products terminate. This sequence is present also at the end of the polymerase (L) gene.This publication has 23 references indexed in Scilit:
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