Genetically Targeted T Cells Eradicate Systemic Acute Lymphoblastic Leukemia Xenografts
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Open Access
- 15 September 2007
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 13 (18), 5426-5435
- https://doi.org/10.1158/1078-0432.ccr-07-0674
Abstract
Purpose: Human T cells targeted to the B cell–specific CD19 antigen through retroviral-mediated transfer of a chimeric antigen receptor (CAR), termed 19z1, have shown significant but partial in vivo antitumor efficacy in a severe combined immunodeficient (SCID)-Beige systemic human acute lymphoblastic leukemia (NALM-6) tumor model. Here, we investigate the etiologies of treatment failure in this model and design approaches to enhance the efficacy of this adoptive strategy.Keywords
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