THE EFFECT OF ESTROGENS ON BONE PHOSPHATE ACCRETION, RESORPTION, AND EXCHANGE IN MICE

Abstract

The effect of estrone on the bone phosphate accretion rate, the size of the exchangeable fraction and resorption has been measured. The estrogen treatment enhanced both accretive and resorptive mechanisms associated with the non-exchangeable bone phosphate while there was little effect upon the size of the exchangeable phosphorus pool. The turnover time of stable bone mineral was reduced from 18.5 to 13.0 days by the treatment. An assay procedure in which an "accretion index" was calculated showed the relative potencies of estrone, estradiol benzoate and diethyl-stilbestrol to be in the ratio of 9:2:1, respectively.