The Mydriatic Response of Mice to Atropine
- 1 September 1963
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 15 (1), 239-250
- https://doi.org/10.1111/j.2042-7158.1963.tb12781.x
Abstract
The time after subcutaneous injection at which atropine produces most mydriasis in male mice increases with increased body-weight. If the response is measured when it is greatest, and is expressed as a percentage of the maximum mydriatic response obtainable in mice of the weight-range used, the mydriatic response to a dose of atropine is constant in male mice weighing from 16 to 50 g. The time-courses of the mydriatic response to atropine in mice of widely differing weights are parallel to the time-courses of the atropine concentration in the cardiac blood of the mice of the same weight-range given a high dose of atropine subcutaneously. The mydriatic response to atropine is found to be increased at times of poor ambient lighting (such as dusk): if however the mice are tested under conditions of artificial lighting (supplemented by daylight when present), the mydriatic response to a standard dose of atropine is nearly constant at all times from 8 a.m. to 2 a.m.Keywords
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