EXPRESSION OF IA ANTIGENS ON IMMUNOCOMPETENT CELLS IN GUINEA-PIG .2. IA ANTIGENS ON MACROPHAGES
- 1 January 1977
- journal article
- research article
- Vol. 119 (5), 1584-1588
Abstract
Only 15-25% of purified oil-induced guinea pig macrophages could be lysed by treatment with anti-Ia [immune response-associated] antigen serum and C [complement]. Those cells remaining alive after treatment were not damaged and were metabolically active since they readily phagocytized latex beads. The Ia-negative macrophages were markedly deficient in their ability to present protein antigens to immune T [thymus-derived] lymphocytes and to function as stimulator cells when mixed with allogeneic T cells in the mixed leukocyte reaction. It appears that Ia antigens are expressed on a subpopulation of macrophages and that this subpopulation plays a critical role in the activation of T cell proliferation to soluble protein antigens and to alloantigens.This publication has 5 references indexed in Scilit:
- Nature of the antigenic complex recognized by T lymphocytes II. T-cell activation by direct modification of macrophage histocompatibility antigens.The Journal of Experimental Medicine, 1977
- EXPRESSION OF IA ANTIGENS ON IMMUNOCOMPETENT CELLS IN GUINEA-PIG .1. DIFFERENTIAL EXPRESSION OF IA ANTIGENS ON T-CELL SUBPOPULATIONS1977
- NATURE OF ANTIGENIC COMPLEX RECOGNIZED BY T-LYMPHOCYTES .4. INHIBITION OF ANTIGEN-SPECIFIC T-CELL PROLIFERATION BY ANTIBODIES TO STIMULATOR MACROPHAGE IA ANTIGENS1977
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