SELECTIVE DISTRIBUTION OF BETA-ADRENOCEPTORS AND ALPHA-1-ADRENOCEPTORS IN RAT LUNG VISUALIZED BY AUTORADIOGRAPHY
- 1 January 1983
- journal article
- research article
- Vol. 266 (2), 308-314
Abstract
The distribution of .beta.- and .alpha.1-adrenoceptors was studied in rat lung by autoradiography using 2 ligands, i.e., [125I]-Iodocyanopindolol for .beta.-adrenoceptors and [125I]-Iodo-BE 2254 [[125I]Iodo-2-[.beta.-(4-hydroxyphenyl) ethylaminomethyl]tetralone] for .alpha.1-adrenoceptors. .beta.-Adrenoceptors were widely distributed in the lung parenchyma and on the walls of the airways (bronchioles). The epithelium of the bronchioles showed a higher density of .beta.-adrenoceptors than the smooth muscle. The blood vessels (veins) seemed to have very few .beta.-adrenoceptors. .alpha.1-Adrenoceptors were found in .apprx. 10-fold smaller amounts than .beta.-adrenoceptors in the lung parenchyma and on the small veins. On the bronchioles, an extremely small number of .alpha.1-adrenoceptors was visible. [An inbalance between .alpha.- and .beta.-adrenoceptors may be involved in allergic asthma.].This publication has 5 references indexed in Scilit:
- BIOCHEMICAL-IDENTIFICATION OF SUBCLASSES OF ADRENOCEPTORS IN GUINEA-PIG, RAT AND HUMAN-LUNG1982
- (±)[125Iodo]cyanopindolol, a new ligand for β-adrenoceptors: Identification and quantitation of subclasses of β-adrenoceptors in guinea pigNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1981
- SIMULTANEOUS DETERMINATION OF BETA-1 AND BETA-2-ADRENERGIC RECEPTORS IN TISSUES CONTAINING BOTH RECEPTOR SUBTYPES1979
- Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscleJournal of Applied Physiology, 1978
- COEXISTENCE OF BETA-1-ADRENOCEPTORS AND BETA-2-ADRENOCEPTORS IN MAMMALIAN LUNG - EVIDENCE FROM DIRECT BINDING STUDIES1978