A Notl restriction map of the entire long arm of human chromosome 21
- 1 August 1993
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 4 (4), 361-366
- https://doi.org/10.1038/ng0893-361
Abstract
A variety of maps of the human genome have been constructed, including cloned DNA maps. We have isolated 40 of the 42 NotI sites that exist on the long arm of human chromosome 21, as NotI linking clones and constructed a complete NotI restriction map spanning the entire region. This map, which provides the most reliable ordering and distance estimation in the region from a pericentromeric locus to the terminus, demonstrates the usefulness of linking clone mapping for analysing human chromosomes.Keywords
This publication has 34 references indexed in Scilit:
- Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisNature, 1993
- Long-distance restriction mapping of the proximal long arm of human chromosome 21 with Not I linking clones.Proceedings of the National Academy of Sciences, 1992
- Linkage of a Gene Causing Familial Amyotrophic Lateral Sclerosis to Chromosome 21 and Evidence of Genetic-Locus HeterogeneityNew England Journal of Medicine, 1991
- Localization of a gene for progressive myoclonus epilepsy to chromosome 21q22.Proceedings of the National Academy of Sciences, 1991
- A genetic linkage map of 27 markers on human chromosome 21Genomics, 1991
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991
- A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresisGenomics, 1991
- Radiation Hybrid Mapping: A Somatic Cell Genetic Method for Constructing High-Resolution Maps of Mammalian ChromosomesScience, 1990
- PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21The Lancet, 1989
- The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21Science, 1987