Studies on transformation of Syrian hamster cells by simian virus 40 (SV40): acquisition of oncogenicity by virus-exposed cells apparently unassociated with the viral genome.
- 1 October 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 54 (4), 1092-1099
- https://doi.org/10.1073/pnas.54.4.1092
Abstract
Lines of Syrian hamster lung and liver cells originally exposed as primary cultures to large doses of SV40 exhibited increased growth rate, high plating efficiency, morphological transformation, and, in some instances, oncogenic potential after unusually long intervals. In at least 2 lines acquisition of oncogenic potential occurred independently of morphological transformation. In none of a total of 11 cell lines studied in detail was conclusive evidence for the presence of the SV40 genome obtained.This publication has 15 references indexed in Scilit:
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