A Comparison of Concurrent and Delayed Tests for Antitumor Activity of L-Asparaginase.
- 1 February 1967
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 124 (2), 568-571
- https://doi.org/10.3181/00379727-124-31793
Abstract
Delayed testing is compared to concurrent testing for the evaluation of chemotherapeutic agents using samples of L-asparaginase as test materials. A large difference in the detection of the antitumor activity of the agents was found, depending upon the method of testing. Guinea pig serum L-asparaginase was quite effective in repressing tumor development when administered within an hr. of tumor inoculation while an L-asparaginase (EC-2) from Escherichia coli was not. The delayed test (treatment given 7 days after tumor inoculation), showed that EC-2 was able to induce complete remission of an established transplant of each of the 3 lymphoid tumors tested (EARAD1, 6C3HED, and P1798). These results draw attention to the value of the delayed test for the screening of potential chemotherapeutic agents.This publication has 6 references indexed in Scilit:
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- Antagonism of Purified Asparaginase from Guinea Pig Serum toward LymphomaScience, 1966
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