Action of Hypophyseal Growth and Thyrotrophic Hormones in Thyroidectomized Rats

Abstract

The animals used were unilaterally nephrectomized rats, drinking 1% NaCl. Effect of a high level of growth hormone (STH) as compared with thyrotropic hormone (TTH) was studied in intact and thyroparathroidectomized animals. The latter operation abolishes the polyuria and hypertension which is produced in intact animals by overdoses of TTH. In the intact rat, STH induces hypertension, nephrosclerosis, polyuria, myocarditis and renal, adrenal and cardiac enlargement. Thyro-parathyroidectomy changes this picture to one of periarteritis nodosa and arthritis with slight renal and cardiac damage.