PHOTOSENSITIZATION IS REQUIRED FOR INACTIVATION OF EQUINE INFECTIOUS ANEMIA VIRUS BY HYPERICIN
- 1 February 1991
- journal article
- research article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 53 (2), 169-174
- https://doi.org/10.1111/j.1751-1097.1991.tb03919.x
Abstract
— Hypericin, a photoreactive polycyclic quinone, was found to dramatically reduce infectivity of cell-free stocks of equine infectious anemia virus. However, the antiviral activity of hypericin was completely dependent on the presence of light. Short periods of photosensitization resulted in a partial loss of reverse transcriptase activity and complete inhibition of viral infectivity. These results suggest that the photodynamic effect of hypericin interferes with more than one stage in the virus replication cycle.Keywords
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