Studies on Absorption and Excretion of Drugs. VI. Effects of Cations and 2, 4-Dinitrophenol on the Transport of Sulfonamides through the Small Intestine of Rat

Abstract

The intestinal absorption of sulfisoxazole was reduced by replacing Na ion in perfusion solution with K ion in vivo. The rates of intestinal transport of sulfonamide, sulfisoxazole and sulfisomezole, also, were decreased by replacing Na ion in circulating solution with K ion in vitro. The transport rate and uptake of sulfisomezole in the intestine were decreased by DNP [214 dinitrophenol] alone, and the combination of the replacing Na ion with K ion and DNP. These of sulfisoxazole and sulfanilamide, however, were not affected by the same treatments.