A network view of disease and compound screening
- 1 April 2009
- journal article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 8 (4), 286-295
- https://doi.org/10.1038/nrd2826
Abstract
The large-scale generation and integration of genomic, proteomic, signalling and metabolomic data are increasingly allowing the construction of complex networks that provide a new framework for understanding the molecular basis of physiological or pathophysiological states. Network-based drug discovery aims to harness this knowledge to investigate and understand the impact of interventions, such as candidate drugs, on the molecular networks that define these states. In this article, we describe how such an approach offers a novel way to understand biology, characterize disease and ultimately develop improved therapies, and discuss the challenges to realizing these goals.Keywords
This publication has 61 references indexed in Scilit:
- Genetics of gene expression and its effect on diseaseNature, 2008
- Variations in DNA elucidate molecular networks that cause diseaseNature, 2008
- A genome-wide association study of global gene expressionNature Genetics, 2007
- Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthmaNature, 2007
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature, 2007
- Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetesNature Genetics, 2007
- Towards a proteome-scale map of the human protein–protein interaction networkNature, 2005
- An integrative genomics approach to infer causal associations between gene expression and diseaseNature Genetics, 2005
- Genetic analysis of genome-wide variation in human gene expressionNature, 2004
- Gene expression profiling predicts clinical outcome of breast cancerNature, 2002