The role of the immune system in uveitis induced in animals
- 1 December 1988
- journal article
- research article
- Published by Springer Nature in Documenta Ophthalmologica
- Vol. 70 (4), 339-351
- https://doi.org/10.1007/bf00157064
Abstract
The etiological diagnosis in many cases of uveitis is hampered by the lack of insight into the pathogenesis of the disease. Animal models might provide clues for the understanding of the ocular and systemic processes leading to this invalidating disease. The immune system seems to play an important role in the pathogenesis of uveitis. Four main topics i.e. autoimmune phenomena, circulating immune complexes, effects of systemic endotoxin and bacterial or viral uveitis are reviewed. Autoimmune phenomena might cause the recurrence of uveitis after presentation of slightly altered self-antigens to the immune system. The endotoxin induced uveitis might be the initial event of recurrent episodes of uveitis caused by the deposition of immune complexes. Endotoxin might play a role in the so called HLA-B27 positive uveitis, mediated through tumour necrosis factor and interleukin-1. In this paper the characteristics of these animal models are described. Attention has been paid to those situations where several of these mechanisms combine in the pathogenesis of ocular diseases.Keywords
This publication has 32 references indexed in Scilit:
- DIFFICULTIES IN THE KNOWLEDGE OF UVEITISActa Ophthalmologica, 2009
- THE HOMOIMMUNE UVEITISES IN THE GUINEA PIG*Annals of the New York Academy of Sciences, 2006
- In vivoandin vitrodeposition of immunoglobulin aggregates in the mouse eyeCurrent Eye Research, 1988
- Antigen-Antibody Reactions in the Eye Involving Complement Binding IgG Antibodies and Their Non-Complement Binding F(ab')2FragmentsImmunological Communications, 1984
- Deposition of immune complexes in the mouse eyeExperimental Eye Research, 1983
- Inflammatory Effects of Endotoxin-Like Contaminants in Commonly Used Protein PreparationsScience, 1977
- Experimental Allergic UveitisInternational Archives of Allergy and Immunology, 1973
- Ocular toxoplasmosis.British Journal of Ophthalmology, 1973
- ENDOTOXÆMIA IN MANThe Lancet, 1972
- Studien zur sympathischen OphthalmieAlbrecht von Graefes Archiv für Ophthalmologie, 1910