Differences in Cell-Cycle Progression Delays after Exposure to 238 Pu a Particles Compared to X Rays
- 1 October 1980
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 84 (1), 16-24
- https://doi.org/10.2307/3575213
Abstract
Cultured Chinese hamster lung cells (V79) were exposed to 238Pu .alpha. particles of 250 k Vp X-rays at doses resulting in similar cell survivals (i.e., 50, 10 and 1%). The DNA distributions of cells at different times after radiation exposure were measured using flow cytometry. After exposure to .alpha. particles V79 cells evidently showed significantly prolonged late S phase delay compared to X-rays for comparable cell-killing doses. Retention of cells in late S subsequent to .alpha.-particle exposure caused a longer mitotic delay compared to X-rays for a given survival level. For the endpoint of mitotic delay the RBE [relative biological effectiveness] for high-LET [linear energy transfer] radiation apparently is higher than the RBE for cell killing.This publication has 2 references indexed in Scilit:
- A heavy particle comparative study. Part IV: acute and late reactionsThe British Journal of Radiology, 1978
- Data acquisition and display for a high-speed cell sorterComputers and Biomedical Research, 1978