Stimulation of serum protein synthesis in ginsenoside treated rat.

Abstract

Ginsenosides Rb₁ and Rc purified from the ethanol extract of a root of Panax ginseng were administered into rats at the dose of 5 mg/100 g of body weight. After 3 hours of the administration, biosynthesis of rat serum protein was stimulated at 2 times and more than the control, in 1 hour ¹⁴C-amino acid incorporation experiment. From the analyses of serum proteins by salting-out, electrophoresis and NaBr flotation, apoproteins of chylomicrons and very low density lipoprotein showed mostly stimulated synthesis by the treatment with ginsenosides. This coincided with the stimulation of cholesterol synthesis reported previously, and a possible relationship between the synthesis of lipids and that of apo-lipo-proteins was discussed.