Histiocytosis

Abstract

HISTIOCYTIC proliferations may result from errors of metabolism, as exemplified by Gaucher's or Niemann–Pick disease; they may appear as primary, apparently neoplastic proliferations, such as histiocytosis X,¹ or as localized visceral or cutaneous tumors, which are generally benign,² or they may be associated with diseases characterized by abnormal responses to infection, such as those reported by Landing and Shirkey.³ The present report describes an unusual form of histiocytosis manifested clinically by testicular enlargement, severe lymphadenopathy, transient hepatomegaly, hypergammaglobulinemia, recurrent infections and rheumatoid arthritis. The clinical and histologic manifestations do not correspond to any previously recognized variants of histiocytosis.Case Report . . .