Effect of Acute Anoxia on the Glutamic Oxalacetic Transaminase Content of the Myocardium of the Rat

Abstract

Transaminase activity in tissues and serum was determined in a group of rats subjected to anoxia and in a control group of animals. There was a 27% decrease in the transaminase activity of the anoxic myocardial tissue without any appreciable change in serum activity. Other tissues which were studied showed that anoxia produces varying decrements in transaminase activity. In vitro studies of tissue taken from anoxic animals indicate that the loss of transaminase activity is not caused by loss or destruction of its coenzyme, pyridoxal phosphate.