Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA
- 1 October 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 305 (5935), 600-605
- https://doi.org/10.1038/305600a0
Abstract
A single U .fwdarw. G transversion in the 3'' consesus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect for this mutation on processing of the 3'' end of the nuclear early region 1A RNA was analyzed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylation but is required for the cleavage step preceding polyadenylation to occur efficiently.Keywords
This publication has 69 references indexed in Scilit:
- The end of the messageNature, 1982
- The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAsCell, 1981
- Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAsCell, 1979
- The major late adenovirus type-2 transcription unit: Termination is downstream from the last poly(A) siteJournal of Molecular Biology, 1979
- Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicingCell, 1978
- Polyoma virus giant RNAs contain tandem repeats of the nucleotide sequence of the entire viral genome.Proceedings of the National Academy of Sciences, 1978
- Mapping the spliced and unspliced late lytic SV40 RNAsCell, 1978
- Analysis of polyoma virus nuclear RNA by mini-blot hybridization.Proceedings of the National Academy of Sciences, 1977
- The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: Mapping of nascent RNA molecular labeled in isolated nucleiCell, 1977
- 3′ Non-coding region sequences in eukaryotic messenger RNANature, 1976